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编 号：F752092
分子式：C15H14O5
分子量：274.27
分子式：C15H14O5
分子量：274.27
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CAS No: 240797-64-2
产品详情
生物活性：
Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research.
体内研究：
Tyrosinase-IN-11 (化合物 11c; 0.5, 1 mM; 局部给药; 每天在紫外线照射前，持续 2 周; 或在连续两周暴露于紫外线灯下，5 天/周，持续 2 周) 在豚鼠体内表现出强大的抗黑色素生成能力。 Animal Model:Female guinea pigs (10 weeks old, 350-500 g) received ultraviolet exposure from a UV lamp
Dosage:0.5, 1 mM
Administration:Topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks
Result:Inhibited the production of melanin in a dose-dependent manner.
体外研究：
Tyrosinase-IN-11 (化合物 11c; 0.1-2 μM; 72 小时) 以剂量依赖性方式降低 TYR 和 MiTF 的蛋白质水平。 Tyrosinase-IN-11 (50 μM) 对人恶性黑色素瘤细胞 A375 和 B16F10 细胞具有轻微的细胞毒性。
Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research.
体内研究：
Tyrosinase-IN-11 (化合物 11c; 0.5, 1 mM; 局部给药; 每天在紫外线照射前，持续 2 周; 或在连续两周暴露于紫外线灯下，5 天/周，持续 2 周) 在豚鼠体内表现出强大的抗黑色素生成能力。 Animal Model:Female guinea pigs (10 weeks old, 350-500 g) received ultraviolet exposure from a UV lamp
Dosage:0.5, 1 mM
Administration:Topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks
Result:Inhibited the production of melanin in a dose-dependent manner.
体外研究：
Tyrosinase-IN-11 (化合物 11c; 0.1-2 μM; 72 小时) 以剂量依赖性方式降低 TYR 和 MiTF 的蛋白质水平。 Tyrosinase-IN-11 (50 μM) 对人恶性黑色素瘤细胞 A375 和 B16F10 细胞具有轻微的细胞毒性。
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