产品
编 号：F752068
分子式：C25H32N4O3S2
分子量：500.68
分子式：C25H32N4O3S2
分子量：500.68
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
结构图
CAS No: 2407227-31-8
产品详情
生物活性：
NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV).
体内研究：
NITD-688 (30 mg/kg, oral gavage, twice daily for 3 days) demonstrates excellent antiviral efficacy in infected AG129 mice.NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies).Animal Model:Infected AG129 mice
Dosage:30 mg/kg
Administration:Oral gavage, twice daily for 3 days
Result:Resulted in a 1.16-log reduction in viremia.
体外研究：
NITD-688 shows antiviral activity against all four serotypes of dengue virus (DENV), with EC50 values of 8 to 38 nM.NITD-688 shows antiviral activity against DENV-2 infected PBMCs, with an EC50 value of 0.94 nM.NITD-688 directly binds to wild-type but not mutant NS4B protein.
NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV).
体内研究：
NITD-688 (30 mg/kg, oral gavage, twice daily for 3 days) demonstrates excellent antiviral efficacy in infected AG129 mice.NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies).Animal Model:Infected AG129 mice
Dosage:30 mg/kg
Administration:Oral gavage, twice daily for 3 days
Result:Resulted in a 1.16-log reduction in viremia.
体外研究：
NITD-688 shows antiviral activity against all four serotypes of dengue virus (DENV), with EC50 values of 8 to 38 nM.NITD-688 shows antiviral activity against DENV-2 infected PBMCs, with an EC50 value of 0.94 nM.NITD-688 directly binds to wild-type but not mutant NS4B protein.
产品资料
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