产品
编 号：F752019
分子式：C24H20ClN3O2
分子量：417.89
分子式：C24H20ClN3O2
分子量：417.89
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 2396639-11-3
产品详情
生物活性：
RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM.
体外研究：
RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples.RB-3 inhibits H2A ubiquitination with an IC50 of 1.6 μM.RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes.RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model.
RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM.
体外研究：
RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples.RB-3 inhibits H2A ubiquitination with an IC50 of 1.6 μM.RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes.RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model.
产品资料
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