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编 号：F752004
分子式：C26H25N3O4
分子量：443.49
分子式：C26H25N3O4
分子量：443.49
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CAS No: 2395009-13-7
产品详情
生物活性：
Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors.
体内研究：
Anticancer agent 48 (20 mg/kg; i.p.; every 2 days for 40 days) shows antitumor effects.Animal Model:8 week-old female BALB/Cnu/nu mice (EZ-2 or T24 cells)
Dosage:20 mg/kg
Administration:I.p.; every 2 days for 40 days
Result:Significantly inhibited cancer cell proliferation, in vivo tumorigenesis, and tumor angiogenesis.
体外研究：
Anticancer agent 48 (compound 48) inhibits tubulin polymerization and MCF-7 cancer cell growth with IC50s of 0.47 μM and 14 nM, respectively.Anticancer agent 48 shows antiproliferative activity with IC50s of 8, 10, 12, 14, 16 nM for KU812, LAMA84-S, LAMA84-R, KBM5-WT, KBM5-T315I cells, respectively.Anticancer agent 48 shows growth inhibition with IC50s of 12, 31, 37, 221, 56, 27, 51, 48, 28, 12 nM for U343G, U87MG, T98G, SK-N-BE, SK-N-BE(2)-C, HT29, HCT116, SW480, SW620, T24 cell, respectively.
Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors.
体内研究：
Anticancer agent 48 (20 mg/kg; i.p.; every 2 days for 40 days) shows antitumor effects.Animal Model:8 week-old female BALB/Cnu/nu mice (EZ-2 or T24 cells)
Dosage:20 mg/kg
Administration:I.p.; every 2 days for 40 days
Result:Significantly inhibited cancer cell proliferation, in vivo tumorigenesis, and tumor angiogenesis.
体外研究：
Anticancer agent 48 (compound 48) inhibits tubulin polymerization and MCF-7 cancer cell growth with IC50s of 0.47 μM and 14 nM, respectively.Anticancer agent 48 shows antiproliferative activity with IC50s of 8, 10, 12, 14, 16 nM for KU812, LAMA84-S, LAMA84-R, KBM5-WT, KBM5-T315I cells, respectively.Anticancer agent 48 shows growth inhibition with IC50s of 12, 31, 37, 221, 56, 27, 51, 48, 28, 12 nM for U343G, U87MG, T98G, SK-N-BE, SK-N-BE(2)-C, HT29, HCT116, SW480, SW620, T24 cell, respectively.
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