产品
编 号：F751969
分子式：C28H35NO3
分子量：433.58
分子式：C28H35NO3
分子量：433.58
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CAS No: 2390042-05-2
产品详情
生物活性：
AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC50s of 0.46?, 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki=?159.8?nM). AChE-IN-14 can be used for the research of Alzheimer’s disease.
体外研究：
AChE-IN-14 (compound 5) has a good affinity to human H3 receptor with a Ki value of 159.8 nM in HEK293 cells.AChE-IN-14 has a high orally activity and cannot cross the blood-brain barrier.AChE-IN-14 (10 μM, 5 min) inhibits hAChE with an IC50 value of 0.48 μM and represents the non-competitive type of eeAChE (Ki = 176 nM) and eqBuChE (Ki = 281 nM) inhibition.
AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC50s of 0.46?, 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki=?159.8?nM). AChE-IN-14 can be used for the research of Alzheimer’s disease.
体外研究：
AChE-IN-14 (compound 5) has a good affinity to human H3 receptor with a Ki value of 159.8 nM in HEK293 cells.AChE-IN-14 has a high orally activity and cannot cross the blood-brain barrier.AChE-IN-14 (10 μM, 5 min) inhibits hAChE with an IC50 value of 0.48 μM and represents the non-competitive type of eeAChE (Ki = 176 nM) and eqBuChE (Ki = 281 nM) inhibition.
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