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编 号：F751932
分子式：C31H46N2O2S
分子量：510.77
分子式：C31H46N2O2S
分子量：510.77
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CAS No: 2387902-92-1
产品详情
生物活性：
Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC50 of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization.
体外研究：
Anticancer agent 64 (compound 5m) increases BAX expression and decreases Bcl-2 protein expression..Anticancer agent 64 shows significant increasement in cells accumulation in the G2/M phase of the cell cycle, while proportion of cells in S phase is reduced.
Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC50 of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization.
体外研究：
Anticancer agent 64 (compound 5m) increases BAX expression and decreases Bcl-2 protein expression..Anticancer agent 64 shows significant increasement in cells accumulation in the G2/M phase of the cell cycle, while proportion of cells in S phase is reduced.
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