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编 号：F751773
分子式：C27H46N2O2
分子量：430.67
分子式：C27H46N2O2
分子量：430.67
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CAS No: 2379310-39-9
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生物活性：
Apoptosis inducer 10 is a potent apoptosis inducer. Apoptosis inducer 10 shows antiproliferative effect. Apoptosis inducer 10 induces apoptosis in HeLa cancer cells via a mitochondria-dependent endogenous pathway.
体外研究：
Apoptosis inducer 10 (compound 11) shows cytotoxic activity with IC50s of 7.39, 63.20, 15.28, 15.38, 12.07 μM for HeLa, HL-7702, A549, PC-3, MCF-7 cells, respectively.Apoptosis inducer 10 (2.5, 5, 10 μM) inhibits tumor cell colony formation in A549, HeLa, PC-3 and MCF-7 cells.Apoptosis inducer 10 (2.5, 5, 10 μM; 48 h) induces apoptosis in HeLa cells in a dose dependent manner.Apoptosis inducer 10 (0, 2.5, 5, 10, 20 μM; 72 h) decreases the ratio to the expression of Bcl-2 and Bax in HeLa cells and resultes in the release of cytochrome c, thereby activates caspase-9 and caspase-3, and cleaved PARP proteins.
Apoptosis inducer 10 is a potent apoptosis inducer. Apoptosis inducer 10 shows antiproliferative effect. Apoptosis inducer 10 induces apoptosis in HeLa cancer cells via a mitochondria-dependent endogenous pathway.
体外研究：
Apoptosis inducer 10 (compound 11) shows cytotoxic activity with IC50s of 7.39, 63.20, 15.28, 15.38, 12.07 μM for HeLa, HL-7702, A549, PC-3, MCF-7 cells, respectively.Apoptosis inducer 10 (2.5, 5, 10 μM) inhibits tumor cell colony formation in A549, HeLa, PC-3 and MCF-7 cells.Apoptosis inducer 10 (2.5, 5, 10 μM; 48 h) induces apoptosis in HeLa cells in a dose dependent manner.Apoptosis inducer 10 (0, 2.5, 5, 10, 20 μM; 72 h) decreases the ratio to the expression of Bcl-2 and Bax in HeLa cells and resultes in the release of cytochrome c, thereby activates caspase-9 and caspase-3, and cleaved PARP proteins.
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