产品
编 号：F751739
分子式：C61H76N12O7S
分子量：1121.4
分子式：C61H76N12O7S
分子量：1121.4
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CAS No: 2378056-80-3
产品详情
生物活性：
A947 is a potent and selective SMARCA2 proteolysis-targeting chimera molecule (PROTAC). A947 also is a potent and moderately selective SMARCA2 degrader. A947 has binding affinity to the SMARCA2 bromodomain with a Kd value of 93 nM. A947 can be used for the research of cancer.
体内研究：
A947 (i.v.; 40 mg/kg; single-dose, 2 week or every other week, 30 days) has active in SMARCA4-mutant NSCLC xenograft models in vivo.Animal Model:SMARCA4-mutant NSCLC xenograft models
Dosage:40mg/kg
Administration:Intravenous , single-dose, 2 week; Intravenous , every other week, 30 days
Result:Rapidly reduced the tumor SMARCA2 protein levels and significant decreased the tumor growth.
体外研究：
A947 has binding affinity to the SMARCA2 and SMARCA4 bromodomains with Kd values of 93 nM and 65 nM, respectively.A947 can potently degrade SMARCA2 in SW1573 cells with a DC50 value of 39 pM.A947 (100 nM, 500 nM) mediates ubiquitination and degradation of SMARCA2/4.A947 (0-500 nM) can inhibit growth of SMARCA4-mutant NSCLC cells.
A947 is a potent and selective SMARCA2 proteolysis-targeting chimera molecule (PROTAC). A947 also is a potent and moderately selective SMARCA2 degrader. A947 has binding affinity to the SMARCA2 bromodomain with a Kd value of 93 nM. A947 can be used for the research of cancer.
体内研究：
A947 (i.v.; 40 mg/kg; single-dose, 2 week or every other week, 30 days) has active in SMARCA4-mutant NSCLC xenograft models in vivo.Animal Model:SMARCA4-mutant NSCLC xenograft models
Dosage:40mg/kg
Administration:Intravenous , single-dose, 2 week; Intravenous , every other week, 30 days
Result:Rapidly reduced the tumor SMARCA2 protein levels and significant decreased the tumor growth.
体外研究：
A947 has binding affinity to the SMARCA2 and SMARCA4 bromodomains with Kd values of 93 nM and 65 nM, respectively.A947 can potently degrade SMARCA2 in SW1573 cells with a DC50 value of 39 pM.A947 (100 nM, 500 nM) mediates ubiquitination and degradation of SMARCA2/4.A947 (0-500 nM) can inhibit growth of SMARCA4-mutant NSCLC cells.
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