产品
编 号：F751704
分子式：C19H16N4O
分子量：316.36
分子式：C19H16N4O
分子量：316.36
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CAS No: 2376841-54-0
产品详情
生物活性：
GABAA receptor agent 8 (compoud 5e) is a potent GABAA receptor positive modulator. GABAA receptor agent 8 shows anticonvulsant activity in vitro and in vivo with low neurotoxicity. GABAA receptor agent 8 has the potential for the research of epilepsy.
体内研究：
GABAA receptor agent 8 (compoud 5e) shows anticonvulsant activity in mice with an ED50 of 40.95 mg/kg and an TD50 of 372.39 mg/kg.GABAA receptor agent 8 specifically attenuates PTZ-induced seizures but not MES-induced seizures in mice.
体外研究：
GABAA receptor agent 8 (compoud 5e) shows anticonvulsant activity with an IC50 of 0.334 μM in 4-AP induced hyper-excitability Model.GABAA receptor agent 8 (0.01-100 μM; 0-140 s) increases GABA-induced activation of GABAA1 receptor in a dose-dependent manner with EC50 12.02 μM.
GABAA receptor agent 8 (compoud 5e) is a potent GABAA receptor positive modulator. GABAA receptor agent 8 shows anticonvulsant activity in vitro and in vivo with low neurotoxicity. GABAA receptor agent 8 has the potential for the research of epilepsy.
体内研究：
GABAA receptor agent 8 (compoud 5e) shows anticonvulsant activity in mice with an ED50 of 40.95 mg/kg and an TD50 of 372.39 mg/kg.GABAA receptor agent 8 specifically attenuates PTZ-induced seizures but not MES-induced seizures in mice.
体外研究：
GABAA receptor agent 8 (compoud 5e) shows anticonvulsant activity with an IC50 of 0.334 μM in 4-AP induced hyper-excitability Model.GABAA receptor agent 8 (0.01-100 μM; 0-140 s) increases GABA-induced activation of GABAA1 receptor in a dose-dependent manner with EC50 12.02 μM.
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