产品
编 号：F751703
分子式：C18H13ClN4O
分子量：336.78
分子式：C18H13ClN4O
分子量：336.78
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CAS No: 2376841-18-6
产品详情
生物活性：
GABAA receptor agent 7 (compoud 5c) is a potent GABAA receptor positive modulator. GABAA receptor agent 7 shows anticonvulsant activity in vitro and in vivo with low neurotoxicity. GABAA receptor agent 7 has the potential for the research of epilepsy.
体内研究：
GABAA receptor agent 7 shows anticonvulsant activity in mice with an ED50 of 31.81 mg/kg and an TD50 of 547.89 mg/kg.GABAA receptor agent 7 specifically attenuates PTZ-induced seizures but not MES-induced seizures in mice.
体外研究：
GABAA receptor agent 7 (compoud 5c) shows anticonvulsant activity with an IC50 of 0.452 μM in 4-AP induced hyper-excitability Model.GABAA receptor agent 7 (0.01-100 μM; 0-140 s) increases GABA-induced activation of GABAA1 receptor in a dose-dependent manner with EC50 3.08 μM.
GABAA receptor agent 7 (compoud 5c) is a potent GABAA receptor positive modulator. GABAA receptor agent 7 shows anticonvulsant activity in vitro and in vivo with low neurotoxicity. GABAA receptor agent 7 has the potential for the research of epilepsy.
体内研究：
GABAA receptor agent 7 shows anticonvulsant activity in mice with an ED50 of 31.81 mg/kg and an TD50 of 547.89 mg/kg.GABAA receptor agent 7 specifically attenuates PTZ-induced seizures but not MES-induced seizures in mice.
体外研究：
GABAA receptor agent 7 (compoud 5c) shows anticonvulsant activity with an IC50 of 0.452 μM in 4-AP induced hyper-excitability Model.GABAA receptor agent 7 (0.01-100 μM; 0-140 s) increases GABA-induced activation of GABAA1 receptor in a dose-dependent manner with EC50 3.08 μM.
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