产品
编 号：F751688
分子式：C19H18NNa2O8P
分子量：465.3
分子式：C19H18NNa2O8P
分子量：465.3
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规格
价格
是否有货
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CAS No: 2376321-67-2
产品详情
生物活性：
IQTub4P is a potent microtubule (MT) inhibitor. IQTub4P has the cytotoxicity in in HeLa cells, with EC50 of 170 nM. IQTub4P inhibits microtubule structure and function. IQTub4P is well-tolerated in vivo.
体内研究：
IQTub4P (Balb/c mice, 25?mg/kg, IP and IV, once every two days, 3 administrations) is well-tolerated in vivo and can avoid short-term cumulative toxicity.Animal Model:Balb/c mice (female)
Dosage:25?mg/kg
Administration:IP and IV, 3 administration, 48?h intervals
Result:Could avoid short-term cumulative toxicity, and was well-tolerated in vivo, with a single-administration maximal tolerated dose of 32?mg/kg (i.p.) and 50?mg/kg (i.v.).
体外研究：
IQTub4P (48 h) shows strong dose-dependent cytotoxicity in HeLa cells.IQTub4P (0-750 nM, 15 min) shows dose-dependent microtubule network depolymerisation, leads to mitotic arrests and the formation of aberrant multipolar spindles with resulting unstructured chromosome alignment at 120 nM.IQTub4P (0-1.25 μM, 24 h) shows potent induction of G2/M arrest.IQTub4P (10 μM, 2 min) shows potent inhibition of cellular tubulin polymerisation dynamics.
IQTub4P is a potent microtubule (MT) inhibitor. IQTub4P has the cytotoxicity in in HeLa cells, with EC50 of 170 nM. IQTub4P inhibits microtubule structure and function. IQTub4P is well-tolerated in vivo.
体内研究：
IQTub4P (Balb/c mice, 25?mg/kg, IP and IV, once every two days, 3 administrations) is well-tolerated in vivo and can avoid short-term cumulative toxicity.Animal Model:Balb/c mice (female)
Dosage:25?mg/kg
Administration:IP and IV, 3 administration, 48?h intervals
Result:Could avoid short-term cumulative toxicity, and was well-tolerated in vivo, with a single-administration maximal tolerated dose of 32?mg/kg (i.p.) and 50?mg/kg (i.v.).
体外研究：
IQTub4P (48 h) shows strong dose-dependent cytotoxicity in HeLa cells.IQTub4P (0-750 nM, 15 min) shows dose-dependent microtubule network depolymerisation, leads to mitotic arrests and the formation of aberrant multipolar spindles with resulting unstructured chromosome alignment at 120 nM.IQTub4P (0-1.25 μM, 24 h) shows potent induction of G2/M arrest.IQTub4P (10 μM, 2 min) shows potent inhibition of cellular tubulin polymerisation dynamics.
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