产品
编 号：F751676
分子式：C45H56ClN9O7
分子量：870.44
分子式：C45H56ClN9O7
分子量：870.44
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 2376136-61-5
产品详情
生物活性：
MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively.
体内研究：
MS170 (a single intraperitoneal injection at a dose of 50 mg/kg) is bioavailable in mice via IP injection.Animal Model:Male Swiss albino mice
Dosage:Single 50 mg/kg(Pharmacokinetic Analysis)
Administration:IP injection over 8 h
Result:Bioavailable in mouse PK studies. The Cmax is1.4 μM at 2 h.
体外研究：
Cereblon (CRBN)-recruiting degrader MS170 is an effective AKT degrader without a ″hook effect″. MS170 selectively induces robust AKT protein degradation, inhibits downstream signaling, and suppresses cancer cell proliferation. MS170 concentration- and time-dependently induces AKT degradation through the ubiquitin-proteasome system (UPS). MS170 (10 nM-10 μM) effectively inhibits the proliferation in multiple cancer cell lines. MS170 (1 nM-10 μM) concentration-dependently depletes cellular total AKT (T-AKT) with the DC50 value of 32±18 nM.
MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively.
体内研究：
MS170 (a single intraperitoneal injection at a dose of 50 mg/kg) is bioavailable in mice via IP injection.Animal Model:Male Swiss albino mice
Dosage:Single 50 mg/kg(Pharmacokinetic Analysis)
Administration:IP injection over 8 h
Result:Bioavailable in mouse PK studies. The Cmax is1.4 μM at 2 h.
体外研究：
Cereblon (CRBN)-recruiting degrader MS170 is an effective AKT degrader without a ″hook effect″. MS170 selectively induces robust AKT protein degradation, inhibits downstream signaling, and suppresses cancer cell proliferation. MS170 concentration- and time-dependently induces AKT degradation through the ubiquitin-proteasome system (UPS). MS170 (10 nM-10 μM) effectively inhibits the proliferation in multiple cancer cell lines. MS170 (1 nM-10 μM) concentration-dependently depletes cellular total AKT (T-AKT) with the DC50 value of 32±18 nM.
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