产品
编 号：F751627
分子式：C18H32ClNO2
分子量：329.91
分子式：C18H32ClNO2
分子量：329.91
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CAS No: 2374723-26-7
产品详情
生物活性：
As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety.
体内研究：
As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration.Animal Model:ICR mice
Dosage:1.08, 0.44, 0.27, and 0.14 g/kg
Administration:IG; single (observed for 7 days)
Result:Exhibited no toxicity to adult mice with intragastric administration, and the LD50 > 1000 mg/kg.
体外研究：
As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV.
As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety.
体内研究：
As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration.Animal Model:ICR mice
Dosage:1.08, 0.44, 0.27, and 0.14 g/kg
Administration:IG; single (observed for 7 days)
Result:Exhibited no toxicity to adult mice with intragastric administration, and the LD50 > 1000 mg/kg.
体外研究：
As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV.
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