产品
编 号：F751583
分子式：C19H18O3
分子量：294.34
分子式：C19H18O3
分子量：294.34
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CAS No: 2368927-41-5
产品详情
生物活性：
Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders.
体内研究：
Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice.
体外研究：
Ph-HTBA can inhibit HOCPCA binding with a Ki value of 1.4 μM.Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM.Ph-HTBA (compound 1i) has a marked hub thermal stabilization effect along with a distinct CaMKIIα Trp403 flip upon binding.
Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders.
体内研究：
Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice.
体外研究：
Ph-HTBA can inhibit HOCPCA binding with a Ki value of 1.4 μM.Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM.Ph-HTBA (compound 1i) has a marked hub thermal stabilization effect along with a distinct CaMKIIα Trp403 flip upon binding.
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