产品
编 号：F751557
分子式：C27H34Cl3N5O2
分子量：566.95
分子式：C27H34Cl3N5O2
分子量：566.95
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
15200
In-stock
1mg
4860
In-stock
5mg
12150
In-stock
结构图
CAS No: 2366152-15-8
产品详情
生物活性：
Zelnecirnon (RPT193) is an orally active inhibitor of CCR4, blocks the recruitment of Th2 inflammatory immune cells into inflamed tissues. Zelnecirnon can be used for allergic inflammation in atopic dermatitis, asthma, and other diseases research.
体内研究：
Zelnecirnon (100 mg/kg; p.o.; once daily; 2 d, 1 d before OVA-challenge) reduces skin inflammation in an acute ovalbumin (OVA)-induced atopic dermatitis model in mice.Animal Model:Acute ovalbumin (OVA)-induced atopic dermatitis model in mouse
Dosage:100 mg/kg
Administration:Oral gavage; once daily; for 2 days, started 1 day before OVA-challenge (in mouse ear)
Result:Decreased the ear thickness significantly.
体外研究：
Zelnecirnon (1 nM-10 μM) inhibits Th2 cells chemotaxis or migration with IC50s of ~370 nM.
Zelnecirnon (RPT193) is an orally active inhibitor of CCR4, blocks the recruitment of Th2 inflammatory immune cells into inflamed tissues. Zelnecirnon can be used for allergic inflammation in atopic dermatitis, asthma, and other diseases research.
体内研究：
Zelnecirnon (100 mg/kg; p.o.; once daily; 2 d, 1 d before OVA-challenge) reduces skin inflammation in an acute ovalbumin (OVA)-induced atopic dermatitis model in mice.Animal Model:Acute ovalbumin (OVA)-induced atopic dermatitis model in mouse
Dosage:100 mg/kg
Administration:Oral gavage; once daily; for 2 days, started 1 day before OVA-challenge (in mouse ear)
Result:Decreased the ear thickness significantly.
体外研究：
Zelnecirnon (1 nM-10 μM) inhibits Th2 cells chemotaxis or migration with IC50s of ~370 nM.
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