产品
编 号：F751526
分子式：C24H24Cl2N2O10Pt
分子量：766.44
分子式：C24H24Cl2N2O10Pt
分子量：766.44
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CAS No: 2364350-07-0
产品详情
生物活性：
DMUP is a potent CD47-SIRPα axis inhibitor. DMUP induces apoptosis and increases the macrophage phagocytosis in A549 cells. DMUP decreases the expression of CD47 and SIRPα protein. DMUP shows antitumor activity.
体内研究：
DMUP (10 mg/kg, i.v., every other day for 17 day) shows antitumor activity.DMUP (5, 10, 20, 40 mg/kg, i.v.,every two days for 18 days) shows no toxicity in mice.Animal Model:ICR mice
Dosage:5, 10, 20, 40 mg/kg
Administration:i.v., every two days, 18 days
Result:Showed low toxicity with LD50 of greater than 20 mg/kg.
Animal Model:A549 xenograft BALB/c nude mice
Dosage:10 mg/kg
Administration:i.v., every other day, 17 day
Result:Showed antitumor activity.
体外研究：
DMUP (72 h) shows antiproliferative activity with IC50s of 0.92, 3.58, 6.29, 1.54 μM for A549, A549/DDP, PANC-1, HepG2 cells, respectively.DMUP (5 μM, 24 h) arrests the cell cycle in S phase in A549 cells.DMUP (5 μM, 48 h) induces apoptosis in A549 cells.DMUP (5 μM, 24 h) decreases the expression of CD47 and SIRPα protein.DMUP (5 μM, 4 h) increases the macrophage phagocytosis in A549-GFP cells.
DMUP is a potent CD47-SIRPα axis inhibitor. DMUP induces apoptosis and increases the macrophage phagocytosis in A549 cells. DMUP decreases the expression of CD47 and SIRPα protein. DMUP shows antitumor activity.
体内研究：
DMUP (10 mg/kg, i.v., every other day for 17 day) shows antitumor activity.DMUP (5, 10, 20, 40 mg/kg, i.v.,every two days for 18 days) shows no toxicity in mice.Animal Model:ICR mice
Dosage:5, 10, 20, 40 mg/kg
Administration:i.v., every two days, 18 days
Result:Showed low toxicity with LD50 of greater than 20 mg/kg.
Animal Model:A549 xenograft BALB/c nude mice
Dosage:10 mg/kg
Administration:i.v., every other day, 17 day
Result:Showed antitumor activity.
体外研究：
DMUP (72 h) shows antiproliferative activity with IC50s of 0.92, 3.58, 6.29, 1.54 μM for A549, A549/DDP, PANC-1, HepG2 cells, respectively.DMUP (5 μM, 24 h) arrests the cell cycle in S phase in A549 cells.DMUP (5 μM, 48 h) induces apoptosis in A549 cells.DMUP (5 μM, 24 h) decreases the expression of CD47 and SIRPα protein.DMUP (5 μM, 4 h) increases the macrophage phagocytosis in A549-GFP cells.
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