产品
编 号：F751502
分子式：C25H27FN2O3
分子量：422.49
分子式：C25H27FN2O3
分子量：422.49
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CAS No: 2361384-14-5
产品详情
生物活性：
Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent with an IC50 value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H2O2-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease.
体外研究：
Neuroinflammatory-IN-2 (compound 7i) (1 and 10 μM) dramatically increases the viability of H2O2-treated PC-12 cells by 70.2% and 81.6% at 1 and 10 μM, respectively.Neuroinflammatory-IN-2 (0.5, 2.5 and 10.0 μM) inhibits NO expression in LPS-stimulated BV-2 cells by 32.4%, 46.7% and 57.2% at the concentration of 0.5, 2.5 and 10.0 μM respectively; and inhibits TNF-α by 35.8%, 53.1% and 76.5%, respectively.
Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent with an IC50 value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H2O2-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease.
体外研究：
Neuroinflammatory-IN-2 (compound 7i) (1 and 10 μM) dramatically increases the viability of H2O2-treated PC-12 cells by 70.2% and 81.6% at 1 and 10 μM, respectively.Neuroinflammatory-IN-2 (0.5, 2.5 and 10.0 μM) inhibits NO expression in LPS-stimulated BV-2 cells by 32.4%, 46.7% and 57.2% at the concentration of 0.5, 2.5 and 10.0 μM respectively; and inhibits TNF-α by 35.8%, 53.1% and 76.5%, respectively.
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