产品
编 号：F751486
分子式：C20H13F2N5NaO3S
分子量：464.4
分子式：C20H13F2N5NaO3S
分子量：464.4
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2361009-23-4
产品详情
生物活性：
PI3K/mTOR Inhibitor-13 sodium is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 sodium has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF).
体内研究：
PI3K/mTOR Inhibitor-13 sodium 的药代动力学 (PK) 参数SpeciesAdministration mannerDose (mg/kg)T1/2 (h)AUClast (ng?h/mL)Cl/F (L/h/kg)Vss (L/kg) F (%)
RatIntravenous injection22.7770690.290.8594.75
MiceIntravenous injection15.45570590.020.1379.3
DogIntravenous injection10.6736720.270.23108.5
MonkeyIntravenous injection19.7059780.160.9259.8
体外研究：
PI3K/mTOR Inhibitor-13 sodium (Compound A) (0-2 μM；48 h) 以剂量依赖性方式抑制 HFL1 细胞的增值。
PI3K/mTOR Inhibitor-13 sodium is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 sodium has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF).
体内研究：
PI3K/mTOR Inhibitor-13 sodium 的药代动力学 (PK) 参数SpeciesAdministration mannerDose (mg/kg)T1/2 (h)AUClast (ng?h/mL)Cl/F (L/h/kg)Vss (L/kg) F (%)
RatIntravenous injection22.7770690.290.8594.75
MiceIntravenous injection15.45570590.020.1379.3
DogIntravenous injection10.6736720.270.23108.5
MonkeyIntravenous injection19.7059780.160.9259.8
体外研究：
PI3K/mTOR Inhibitor-13 sodium (Compound A) (0-2 μM；48 h) 以剂量依赖性方式抑制 HFL1 细胞的增值。
产品资料
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