产品
编 号:F751462
分子式:C26H29N3O6S
分子量:511.59
产品类型
结构图
CAS No: 2356229-14-4
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产品详情
生物活性:
T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity.
体内研究:
T01-1 (1 mg/kg; i.v.; single) shows T1/2 values of 2.78 and 1.97 h in female and male rats, respectively.Animal Model:Sprague Dawley rat (half male and half female).
Dosage:1 mg/kg
Administration:Intravenous injection; single
Result:1.19Pharmacokinetic Parameters of T01-1 in Sprague Dawley rat .IV (1 mg/kg)
FemaleMale
AUCLast (ng/mL?h)437214
Cmax (ng/mL)838625
MRTINF (h)2.810.44
T1/2 (h)2.781.97
Tmax (h)0.080.08
体外研究:
T01-1 (0-50 nM; 3 days) anti-proliferative activity in HCC1806 cells.