产品
编 号：F751335
分子式：C20H19F3N6O3S2
分子量：512.53
分子式：C20H19F3N6O3S2
分子量：512.53
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
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25mg
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询价
结构图
CAS No: 2338811-71-3
产品详情
生物活性：
CTP Synthetase-IN-1 is a potent, orally active cytidine 5'-triphosphate synthetase (CTPS) inhibitor with IC50s of 32 nM and 18 nM for human CTPS1 and human CTPS2, respectively. CTP Synthetase-IN-1 has anti-inflammatory effects.
体内研究：
CTP Synthetase-IN-1 (compound 27; 10-50 mg/kg; p.o; twice daily; for 18 days) shows significant pharmacological responses in collagen-induced arthritis (CIA) model.Animal Model:Mouse collagen-induced arthritis (CIA) model
Dosage:10 mg/kg and 50 mg/kg
Administration:p.o; twice daily; for 18 days
Result:Resulted in improvements in specific indicators of disease severity.
体外研究：
CTP Synthetase-IN-1 (compound 27) inhibits rat CTPS1, rat CTPS2, mouse CTPS1, and mouse CTPS2 with IC50 values of 27 nM, 23 nM, 26 nM, and 33 nM, respectively.
CTP Synthetase-IN-1 is a potent, orally active cytidine 5'-triphosphate synthetase (CTPS) inhibitor with IC50s of 32 nM and 18 nM for human CTPS1 and human CTPS2, respectively. CTP Synthetase-IN-1 has anti-inflammatory effects.
体内研究：
CTP Synthetase-IN-1 (compound 27; 10-50 mg/kg; p.o; twice daily; for 18 days) shows significant pharmacological responses in collagen-induced arthritis (CIA) model.Animal Model:Mouse collagen-induced arthritis (CIA) model
Dosage:10 mg/kg and 50 mg/kg
Administration:p.o; twice daily; for 18 days
Result:Resulted in improvements in specific indicators of disease severity.
体外研究：
CTP Synthetase-IN-1 (compound 27) inhibits rat CTPS1, rat CTPS2, mouse CTPS1, and mouse CTPS2 with IC50 values of 27 nM, 23 nM, 26 nM, and 33 nM, respectively.
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