产品
编 号：F751326
分子式：C11H14N4O2
分子量：234.25
分子式：C11H14N4O2
分子量：234.25
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CAS No: 233605-81-7
产品详情
生物活性：
AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 μM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases.
体外研究：
AV123 (0.01-100 μM; 24 h) efficiently blocks necroptosis in a dose-dependent manner in FADD-deficient Jurkat cells.AV123 (0.01-50 μM; 24 h) shows no toxicity to RPE-1 cells.
AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 μM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases.
体外研究：
AV123 (0.01-100 μM; 24 h) efficiently blocks necroptosis in a dose-dependent manner in FADD-deficient Jurkat cells.AV123 (0.01-50 μM; 24 h) shows no toxicity to RPE-1 cells.
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