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编 号：F751243
分子式：C225H346N56O65
分子量：4875.49
分子式：C225H346N56O65
分子量：4875.49
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CAS No: 2315504-40-4
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生物活性：
DA-JC4 is a dual GLP-1/GIP receptor agonist and can be used for the research of neurological disease and insulin signaling pathways.
体内研究：
DA-JC4 (10 nmol/kg; i.p.; once-daily for 14 days) significantly prevents spatial learning deficits in a Y- maze test and Morris water maze tests, and decreases phosphorylated tau levels in the rat cerebral cortex and hippocampus.DA-JC4 (25 nmol/kg; i.p.; 6 days) shows high levels expression of tyrosine Hydroxylase in the s. nigra and increases expression of neuroprotective growth factor Glial-Derived Neurotrophic Factor (GDNF). DA-JC4 (50 nmol/kg; i.p.; once-daily for 7 days) improves Parkinson's disease symptom potentially and enhances neurotransmission.Animal Model:Male Sprague-Dawley rats (210–230 g)
Dosage:10 nmol/kg
Administration:I.p.
Result:Significantly prevented spatial learning deficits in a Y- maze test and Morris water maze tests, and decreased phosphorylated tau levels in the rat cerebral cortex and hippocampus.
Animal Model:Adult male C57BL/6 mice (8 week-old)
Dosage:25 nmol/kg/day
Administration:I.p.
Result:Showed high levels expression of tyrosine Hydroxylase in the s. nigra and increased expression of neuroprotective growth factor Glial-Derived Neurotrophic Factor (GDNF).
Animal Model:Adult male Sprague-Dawley (SD) rats (230-280 g)
Dosage:50 nmol/kg
Administration:I.p.
Result:Improved Parkinson's disease symptom potentially and enhanced neurotransmission.
体外研究：
DA-JC4 (1~100 nM; hippocampal cells) inhibits rotenone-induced hippocampal neuron death and significantly suppresses Cyt C, Bax and Caspase activation.
DA-JC4 is a dual GLP-1/GIP receptor agonist and can be used for the research of neurological disease and insulin signaling pathways.
体内研究：
DA-JC4 (10 nmol/kg; i.p.; once-daily for 14 days) significantly prevents spatial learning deficits in a Y- maze test and Morris water maze tests, and decreases phosphorylated tau levels in the rat cerebral cortex and hippocampus.DA-JC4 (25 nmol/kg; i.p.; 6 days) shows high levels expression of tyrosine Hydroxylase in the s. nigra and increases expression of neuroprotective growth factor Glial-Derived Neurotrophic Factor (GDNF). DA-JC4 (50 nmol/kg; i.p.; once-daily for 7 days) improves Parkinson's disease symptom potentially and enhances neurotransmission.Animal Model:Male Sprague-Dawley rats (210–230 g)
Dosage:10 nmol/kg
Administration:I.p.
Result:Significantly prevented spatial learning deficits in a Y- maze test and Morris water maze tests, and decreased phosphorylated tau levels in the rat cerebral cortex and hippocampus.
Animal Model:Adult male C57BL/6 mice (8 week-old)
Dosage:25 nmol/kg/day
Administration:I.p.
Result:Showed high levels expression of tyrosine Hydroxylase in the s. nigra and increased expression of neuroprotective growth factor Glial-Derived Neurotrophic Factor (GDNF).
Animal Model:Adult male Sprague-Dawley (SD) rats (230-280 g)
Dosage:50 nmol/kg
Administration:I.p.
Result:Improved Parkinson's disease symptom potentially and enhanced neurotransmission.
体外研究：
DA-JC4 (1~100 nM; hippocampal cells) inhibits rotenone-induced hippocampal neuron death and significantly suppresses Cyt C, Bax and Caspase activation.
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