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编 号:F751198
分子式:C29H28FN5O
分子量:481.56
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CAS No: 2308504-22-3
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JBI-589 is a non-covalent PAD4 isoform-selective inhibitor. JBI-589 reduces CXCR2 expression and blocks neutrophil chemotaxis. JBI-589 reduces primary tumor and metastases, and enhances the anti-tumor effect of checkpoint inhibitors.