产品
编 号：F751192
分子式：C28H28ClN5O4S
分子量：566.07
分子式：C28H28ClN5O4S
分子量：566.07
产品类型
规格
价格
是否有货
结构图
CAS No: 2307699-34-7
产品详情
生物活性：
Thi-DPPY (compound 8e) is a potent and orally active JAK3 inhibitor with IC50 values of 62.4, 1.38 nM for BTK, JAK, respectively. Thi-DPPY shows anti-proliferative activity against HBE cells. Thi-DPPY shows anti-inflammatory activity in vivo. Thi-DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF).
体内研究：
DPPY (30, 60 mg/kg; i.g., once daily for 14 days) shows anti-IPF agents on the lung morphology and lung coefficient in mouse model.DPPY (30, 60 mg/kg) significantly decreases the expression of IL-6, IL-17A, TNF-α and MDA in lung tissue in a dose dependent manner.Animal Model:5-6 week old, 20-25 g, C57BL mice (BLM-induced pulmonary inflammation and pulmonary fibrosis model)
Dosage:30, 60 mg/kg
Administration:I.g.; once daily for 14 days
Result:Attenuated the pulmonary morphology changes and reduced the collagen disposition induced by BLM in mouse lung.
体外研究：
DPPY (compound 8e) shows anti-proliferative activity against HBE (human bronchial epithelia) cells with an IC50 of 39.0 μM.
Thi-DPPY (compound 8e) is a potent and orally active JAK3 inhibitor with IC50 values of 62.4, 1.38 nM for BTK, JAK, respectively. Thi-DPPY shows anti-proliferative activity against HBE cells. Thi-DPPY shows anti-inflammatory activity in vivo. Thi-DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF).
体内研究：
DPPY (30, 60 mg/kg; i.g., once daily for 14 days) shows anti-IPF agents on the lung morphology and lung coefficient in mouse model.DPPY (30, 60 mg/kg) significantly decreases the expression of IL-6, IL-17A, TNF-α and MDA in lung tissue in a dose dependent manner.Animal Model:5-6 week old, 20-25 g, C57BL mice (BLM-induced pulmonary inflammation and pulmonary fibrosis model)
Dosage:30, 60 mg/kg
Administration:I.g.; once daily for 14 days
Result:Attenuated the pulmonary morphology changes and reduced the collagen disposition induced by BLM in mouse lung.
体外研究：
DPPY (compound 8e) shows anti-proliferative activity against HBE (human bronchial epithelia) cells with an IC50 of 39.0 μM.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备