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编 号：F751006
分子式：C24H37N3O
分子量：383.57
分子式：C24H37N3O
分子量：383.57
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CAS No: 2304818-41-3
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生物活性：
BChE-IN-4 is a potent and cross the blood-brain barrier BChE inhibitor. BChE-IN-4 attenuates learning and memory deficits caused by cholinergic deficit in mouse model. BChE-IN-4 has the potential for the research of alzheimer’s disease.
体内研究：
BChE-IN-4 (compound 1) (10, 20, 30 mg/kg) attenuates learning and memory deficits caused by cholinergic deficit in AD mouse model.BChE-IN-4 (30 mg/kg) dose not induce adverse motor effects in vivo.Animal Model:Adult male Albino Swiss CD-1 mice (Scopolamine-induced memory-impaired CD-1 mice)
Dosage:10, 20, 30 mg/kg
Administration:I.p.
Result:Significantly prolonged the step-through latencies in memory impaired mice.
Animal Model:18-22 g, C57BL/6J mice
Dosage:30 mg/kg
Administration:I.p.
Result:Did not enhance learning abilities and working memory in the acquisition phase or the short-term memory retrieval on day 5, but did significantly improve long-term memory retrieval, as observed on day 12 of the BM ( Barnes maze) task.
Animal Model:Mice
Dosage:30 mg/kg (suspended in 1% Tween 80)
Administration:I.p
Result:Neither altered the number of light-beam interruptions in the locomotor activity test nor induced any motor deficits at 6, 18 and 24 rpm in the rotarod test.
BChE-IN-4 is a potent and cross the blood-brain barrier BChE inhibitor. BChE-IN-4 attenuates learning and memory deficits caused by cholinergic deficit in mouse model. BChE-IN-4 has the potential for the research of alzheimer’s disease.
体内研究：
BChE-IN-4 (compound 1) (10, 20, 30 mg/kg) attenuates learning and memory deficits caused by cholinergic deficit in AD mouse model.BChE-IN-4 (30 mg/kg) dose not induce adverse motor effects in vivo.Animal Model:Adult male Albino Swiss CD-1 mice (Scopolamine-induced memory-impaired CD-1 mice)
Dosage:10, 20, 30 mg/kg
Administration:I.p.
Result:Significantly prolonged the step-through latencies in memory impaired mice.
Animal Model:18-22 g, C57BL/6J mice
Dosage:30 mg/kg
Administration:I.p.
Result:Did not enhance learning abilities and working memory in the acquisition phase or the short-term memory retrieval on day 5, but did significantly improve long-term memory retrieval, as observed on day 12 of the BM ( Barnes maze) task.
Animal Model:Mice
Dosage:30 mg/kg (suspended in 1% Tween 80)
Administration:I.p
Result:Neither altered the number of light-beam interruptions in the locomotor activity test nor induced any motor deficits at 6, 18 and 24 rpm in the rotarod test.
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