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编 号:F750821
分子式:C56H79N9O14
分子量:1102.28
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生物活性:
Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp..

体内研究:
Aminocandin (1-10 mg/kg; i.v. or i.p.; once daily for 11 days) is highly effective in reducing mortality and organ burden in disseminated infection caused by ITC-susceptible and -resistant A. fumigatus in mice.Aminocandin (5 and 10 mg/kg; i.v.; once or twice a week for 4 weeks) is an effective addition to the arsenal of antifungal compounds for the treatment of candidiasis caused byFluconazole (HY-B0101)-resistant C. albicans in immunocompetent mice.Animal Model:Immunosuppressed male CD1 mice, Aspergillus fumigatus infection model
Dosage:10, 5, 1 and 0.25 mg/kg (IV) or 1 mg/kg (IP)
Administration:IV or IP, once daily for 11 days
Result:Increased the survival rate, 5 mg/kg i.v. yielded 100% survival following infection with AF91.

体外研究:
Aminocandin (HMR 3270) inhibitsFluconazole (HY-B0101)-resistant C. albicans strain MRL 648 with an MIC of 0.25 mg/L.Aminocandin shows half-life of 48-58 h.
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