产品
编 号:F750693
分子式:C210H322N46O67
分子量:4563.06
产品类型
结构图
CAS No: 2259884-03-0
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产品详情
生物活性:
Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D).
体内研究:
Mazdutide (15, 30 nmol/kg; sc; 单剂量) 在饮食诱导肥胖 (DIO) 的糖尿病小鼠中,可显著减轻小鼠体重和实物摄入量。