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编 号：F750647
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1mg
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CAS No: 2254086-60-5
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生物活性：
Tusamitamab ravtansine (SAR-408701) is a targeted ADC against tumor cells expressing CEACAM5, composed of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent, maytansinoid DM4 (HY-12454), via a cleavable linker. Tusamitamab ravtansine has an average drug-to-antibody ratio (DAR) of 3.8.
体外研究：
Tusamitamab ravtansine (SAR-408701) 的抗体成分与 CEACAM5 的胞外结构域结合，启动 ADC 内化到肿瘤细胞中，随后在细胞质内释放 DM4。DM4 通过破坏微管组装、诱导细胞周期停滞和启动细胞凋亡来引发细胞毒性作用。
Tusamitamab ravtansine (SAR-408701) is a targeted ADC against tumor cells expressing CEACAM5, composed of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent, maytansinoid DM4 (HY-12454), via a cleavable linker. Tusamitamab ravtansine has an average drug-to-antibody ratio (DAR) of 3.8.
体外研究：
Tusamitamab ravtansine (SAR-408701) 的抗体成分与 CEACAM5 的胞外结构域结合，启动 ADC 内化到肿瘤细胞中，随后在细胞质内释放 DM4。DM4 通过破坏微管组装、诱导细胞周期停滞和启动细胞凋亡来引发细胞毒性作用。
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