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编 号：F750598
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1mg
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CAS No: 2251756-52-0
产品详情
生物活性：
Pacanalotamab (AMG 420; BI-836909) is a bispecific T-cell engager (BiTE) targeting to BCMA and CD3?. BCMA refers to B cell maturation antigen, as Pacanalotamab redirecting T cells to BCMA expressing cells on the cell surface. Pacanalotamab conducts T-cell redirected lysis of human multiple myeloma (MM) cell lines.
体内研究：
Pacanalotamab (50 μg/kg/天；静脉内或皮下注射；持续 18 天) 在小鼠 NCI-H929 异种移植模型中表现出抗肿瘤活性。Pacanalotamab (5 μg/kg/天；静脉注射或皮下注射) 在小鼠原位 L-363 异种移植模型中显着延长小鼠的存活时间。Pacanalotamab (静脉注射，135 μg/kg/天，或皮下注射，405 μg/kg/天；共 7 天) 耐受性良好，在毒性研究中它减少了猕猴骨髓中的浆细胞。Animal Model:Cynomolgus monkey studies
Dosage:(1) 0, 5, 15, 45 or 135?μg/kg/day, 20?mL/kg/day; (2) 135 or 405?μg/kg/day, 2?mL/kg/day
Administration:Intravenous injection for (1) and subcutaneous injection for (2); for 7 days
Result:Showed well tolerated among Cynomolgus monkeys. Clinical signs of toxicity were limited to vomiting and increased body temperature at 4-8 h.
体外研究：
Pacanalotamab (1 pg/mL-100 ng/mL；24 h) 通过 T 细胞激活诱导 BCMA 依赖性肿瘤细胞裂解。Pacanalotamab 诱导人多发性骨髓瘤细胞系的剂量依赖性重定向裂解，EC90 值范围为 16-810 pg/mL。Pacanalotamab (100 ng/mL；24 小时) 诱导磷脂酰丝氨酸从质膜内层转移到外层，导致 MM.1R 细胞凋亡。
Pacanalotamab (AMG 420; BI-836909) is a bispecific T-cell engager (BiTE) targeting to BCMA and CD3?. BCMA refers to B cell maturation antigen, as Pacanalotamab redirecting T cells to BCMA expressing cells on the cell surface. Pacanalotamab conducts T-cell redirected lysis of human multiple myeloma (MM) cell lines.
体内研究：
Pacanalotamab (50 μg/kg/天；静脉内或皮下注射；持续 18 天) 在小鼠 NCI-H929 异种移植模型中表现出抗肿瘤活性。Pacanalotamab (5 μg/kg/天；静脉注射或皮下注射) 在小鼠原位 L-363 异种移植模型中显着延长小鼠的存活时间。Pacanalotamab (静脉注射，135 μg/kg/天，或皮下注射，405 μg/kg/天；共 7 天) 耐受性良好，在毒性研究中它减少了猕猴骨髓中的浆细胞。Animal Model:Cynomolgus monkey studies
Dosage:(1) 0, 5, 15, 45 or 135?μg/kg/day, 20?mL/kg/day; (2) 135 or 405?μg/kg/day, 2?mL/kg/day
Administration:Intravenous injection for (1) and subcutaneous injection for (2); for 7 days
Result:Showed well tolerated among Cynomolgus monkeys. Clinical signs of toxicity were limited to vomiting and increased body temperature at 4-8 h.
体外研究：
Pacanalotamab (1 pg/mL-100 ng/mL；24 h) 通过 T 细胞激活诱导 BCMA 依赖性肿瘤细胞裂解。Pacanalotamab 诱导人多发性骨髓瘤细胞系的剂量依赖性重定向裂解，EC90 值范围为 16-810 pg/mL。Pacanalotamab (100 ng/mL；24 小时) 诱导磷脂酰丝氨酸从质膜内层转移到外层，导致 MM.1R 细胞凋亡。
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