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编 号:F750588
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CAS No: 2250440-41-4
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生物活性:
Vilobelimab (CaCP-29, IFX-1) is a monoclonal anti-C5a antibody to the allergen C5a, a pro-inflammatory complement division product that plays a central role in mediating organ dysfunction. Vilobelimab acts as a C5a inhibitor, inhibiting neutrophil activation, chemotaxis, and reducing inflammatory signalling, and may be used in studies related to sepsis, COVID-19, etc.
体外研究:
Vilobelimab 以剂量依赖的方式选择性地中和 C5a,而不阻断膜攻击复合物的形成,也不会导致可检测到的安全问题 在对患有严重败血症和败血性休克的病人进行的某些临床研究中。