产品
编 号：F750500
分子式：C4H12NO6P
分子量：201.11
分子式：C4H12NO6P
分子量：201.11
产品类型
规格
价格
是否有货
结构图
CAS No: 2247534-79-6
产品详情
生物活性：
L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.
体内研究：
L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction.Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats.Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion.Animal Model:Rats.
Dosage:5-30 μg.
Administration:Intrathecal inhection 4-5 days.
Result:Dose-dependently increased paw withdrawal threshold.
L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.
体内研究：
L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction.Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats.Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion.Animal Model:Rats.
Dosage:5-30 μg.
Administration:Intrathecal inhection 4-5 days.
Result:Dose-dependently increased paw withdrawal threshold.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备