产品
编 号:F750281
分子式:C17H15F3N2O
分子量:320.31
产品类型
结构图
CAS No: 2242957-52-2
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产品详情
生物活性:
UCB-J is a positron emission tomography (PET) radioligand for the synaptic vesicle protein 2A (SV2A).
体内研究:
UCB-J exhibits high free fraction (0.46 ± 0.02) and metabolizes at a moderate rate (39% ± 5% and 24% ± 3% parent remaining at 30 and 90 min) in plasma. UCB-J displays high uptake and fast kinetics in the monkey brain. When the animal is pretreated with UCB-J (150 μg/kg, iv), the whole brain SUV decreases to the same level as centrum semiovale, indicating the in vivo binding specificity of [18F]7 to SV2A.