产品
编 号：F750277
分子式：C23H24N2O7
分子量：440.45
分子式：C23H24N2O7
分子量：440.45
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CAS No: 2242792-25-0
产品详情
生物活性：
AChE-IN-15 (Compound 3d) is a reversible human acetylcholinesterase (huAChE) (IC50=6.8 μM) and human butyrylcholinesterase (huBChE) (IC50=16.1 μM) inhibitor. AChE-IN-15 shows significant antioxidant potency, AChE-IN-15 can be used for the research of Alzheimer’s disease.
体内研究：
AChE-IN-15 (compound 3d) (5-20 mg/kg; 14 days; Kunming mice) can reverse cognitive deficit.Animal Model:Kunming mice
Dosage:5, 10 and 20 mg/kg
Administration:for 14 days
Result:Reversed cognitive deficit induced by scopolamine.
体外研究：
AChE-IN-15 (compound 3d) inhibits huAChE and huBChE with IC50 values of 6.8 and 16.1 μM and inhibits RatAChE and RatBChE with IC50 values of 4.7 and 12.1μM.AChE-IN-15 (compound 3d) (25 μM) inhibits self-mediated aggregation (77.9), huAChE-induced Aβ1-42 aggregation (73.6%), inhibit (78.9%) and disaggregate (64.6%) Cu2+-mediated Cu2+-mediated aggregation.AChE-IN-15 (compound 3d) (25 μM) is an neuroprotective agent and displays hepatoprotective activity.AChE-IN-15 (compound 3d) (25 μM) shows good blood-brain barrier (BBB) penetration.AChE-IN-15 (compound 3d) (5-10 μM) displays neuroprotective effect on Aβ1-42-induced SH-SY5Y neurotoxicity.
AChE-IN-15 (Compound 3d) is a reversible human acetylcholinesterase (huAChE) (IC50=6.8 μM) and human butyrylcholinesterase (huBChE) (IC50=16.1 μM) inhibitor. AChE-IN-15 shows significant antioxidant potency, AChE-IN-15 can be used for the research of Alzheimer’s disease.
体内研究：
AChE-IN-15 (compound 3d) (5-20 mg/kg; 14 days; Kunming mice) can reverse cognitive deficit.Animal Model:Kunming mice
Dosage:5, 10 and 20 mg/kg
Administration:for 14 days
Result:Reversed cognitive deficit induced by scopolamine.
体外研究：
AChE-IN-15 (compound 3d) inhibits huAChE and huBChE with IC50 values of 6.8 and 16.1 μM and inhibits RatAChE and RatBChE with IC50 values of 4.7 and 12.1μM.AChE-IN-15 (compound 3d) (25 μM) inhibits self-mediated aggregation (77.9), huAChE-induced Aβ1-42 aggregation (73.6%), inhibit (78.9%) and disaggregate (64.6%) Cu2+-mediated Cu2+-mediated aggregation.AChE-IN-15 (compound 3d) (25 μM) is an neuroprotective agent and displays hepatoprotective activity.AChE-IN-15 (compound 3d) (25 μM) shows good blood-brain barrier (BBB) penetration.AChE-IN-15 (compound 3d) (5-10 μM) displays neuroprotective effect on Aβ1-42-induced SH-SY5Y neurotoxicity.
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