产品
编 号：F750257
分子式：C22H18ClN5O3
分子量：435.86
分子式：C22H18ClN5O3
分子量：435.86
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CAS No: 2241914-86-1
产品详情
生物活性：
Aurora Kinases-IN-2 (compound 12Aj) is a potent Aurora kinases inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora Kinases-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora Kinases-IN-2 can be used for cancer research.
体外研究：
Aurora Kinases-IN-2 (compound 12Aj) (72 hours) has antiproliferative activity with IC50 values of 11.5 μM, 1.34 μM, 7.30 μM and 1.64 μM for U87, HeLa, HepG2 and LoVo tumor cell lines, respectively.Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) inhibits Aurora A and Aurora B in HeLa cells.Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours; HeLa cells) results in G2/M accumulation by regulating the expression of Cyclin B1 and cdc2.Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) blocks phosphorylation of Aurora kinases in HeLa cells.
Aurora Kinases-IN-2 (compound 12Aj) is a potent Aurora kinases inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora Kinases-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora Kinases-IN-2 can be used for cancer research.
体外研究：
Aurora Kinases-IN-2 (compound 12Aj) (72 hours) has antiproliferative activity with IC50 values of 11.5 μM, 1.34 μM, 7.30 μM and 1.64 μM for U87, HeLa, HepG2 and LoVo tumor cell lines, respectively.Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) inhibits Aurora A and Aurora B in HeLa cells.Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours; HeLa cells) results in G2/M accumulation by regulating the expression of Cyclin B1 and cdc2.Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) blocks phosphorylation of Aurora kinases in HeLa cells.
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