产品
编 号：F750176
分子式：C223H417N89O50S
分子量：5177.33
分子式：C223H417N89O50S
分子量：5177.33
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规格
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CAS No: 2232156-31-7
产品详情
生物活性：
Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity. Apoptin-derived peptide promotes apoptosis and necrosis of gastric cancer (GC) cells by regulating PI3K/AKT/ARNT signaling. Apoptin-derived peptide inhibited the invasion and migration of cancer cells, and inhibited the expression and phosphorylation of the subunit p85 of PI3K, which further inhibited the PI3K/AKT pathway involved in the development of gastric cancer.
体外研究：
Apoptin-derived peptide (40-100 μg/mL, 24 h) 通过抑制 PI3K/AKT 信号通路促进 ARNT 下调，从而逆转 SGC-7901/CDDP 细胞对 CDDP 的耐药性。Apoptin-derived peptide (10-30 μg/mL, 24 h) 抑制 SGC-7901、SGC-7901/CDDP 和 MGC-803 细胞的迁移和侵袭。Apoptin-derived peptide (30-60 μg/mL, 24 h) 增加 SGC-7901/CDDP 细胞对 CDDP 的敏感性。Apoptin-derived peptide (10-20 μg/mL, 24 h) 增加 SGC-7901/CDDP 细胞的 G2/M 期细胞比例并诱导细胞凋亡。Apoptin-derived peptide (10-70 μg/mL, 4-24 h) 对胃癌细胞有很好的抑制作用。
Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity. Apoptin-derived peptide promotes apoptosis and necrosis of gastric cancer (GC) cells by regulating PI3K/AKT/ARNT signaling. Apoptin-derived peptide inhibited the invasion and migration of cancer cells, and inhibited the expression and phosphorylation of the subunit p85 of PI3K, which further inhibited the PI3K/AKT pathway involved in the development of gastric cancer.
体外研究：
Apoptin-derived peptide (40-100 μg/mL, 24 h) 通过抑制 PI3K/AKT 信号通路促进 ARNT 下调，从而逆转 SGC-7901/CDDP 细胞对 CDDP 的耐药性。Apoptin-derived peptide (10-30 μg/mL, 24 h) 抑制 SGC-7901、SGC-7901/CDDP 和 MGC-803 细胞的迁移和侵袭。Apoptin-derived peptide (30-60 μg/mL, 24 h) 增加 SGC-7901/CDDP 细胞对 CDDP 的敏感性。Apoptin-derived peptide (10-20 μg/mL, 24 h) 增加 SGC-7901/CDDP 细胞的 G2/M 期细胞比例并诱导细胞凋亡。Apoptin-derived peptide (10-70 μg/mL, 4-24 h) 对胃癌细胞有很好的抑制作用。
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