产品
编 号：F750148
分子式：C21H25ClN4O2
分子量：400.9
分子式：C21H25ClN4O2
分子量：400.9
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2231664-45-0
产品详情
生物活性：
BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain.
体内研究：
BMT-090605 hydrochloride(intrathecal; 0.3-3 μg/rat) causes antinociception by inhibiting AAK1 in the spinal cord.Animal Model:Male Sprague-Dawley rats (chronic constriction injury (CCI) model)
Dosage:0.3-3 μg/rat
Administration:Intrathecal
Result:Caused a dose-dependent reduction in thermal hyperalgesia.
体外研究：
BMT-090605 hydrochloride shows AAK1inhibitory activity with an IC50 of 0.63 nM.BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively.
BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain.
体内研究：
BMT-090605 hydrochloride(intrathecal; 0.3-3 μg/rat) causes antinociception by inhibiting AAK1 in the spinal cord.Animal Model:Male Sprague-Dawley rats (chronic constriction injury (CCI) model)
Dosage:0.3-3 μg/rat
Administration:Intrathecal
Result:Caused a dose-dependent reduction in thermal hyperalgesia.
体外研究：
BMT-090605 hydrochloride shows AAK1inhibitory activity with an IC50 of 0.63 nM.BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备