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编 号:F750118
分子式:C20H17Cl2FN4OS
分子量:451.34
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CAS No: 2230873-75-1
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生物活性:
KRAS inhibitor-15 (compound 3-19) is a potent KRAS G12C inhibitor with an IC50 of 0.954 μM. KRAS inhibitor-15 shows p-ERK inhibition activities with IC50s of 2.03, >33.3 μM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-15 has the potential for the research of pancreatic, colorectal, and lung cancers.