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编 号：F750081
分子式：C12H12O9
分子量：300.22
分子式：C12H12O9
分子量：300.22
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CAS No: 222973-44-6
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生物活性：
Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. Mumefural inhibits platelet aggregation. Mumefural shows anti-thrombotic effects and ameliorates cognitive impairment.
体内研究：
Mumefural (0.1-10 mg/kg; i.p.; once) 在大鼠中显示抗血栓作用。Mumefural (20-80 mg/kg; oral; daily for 42 days) 通过调节中隔海马胆碱能系统和神经炎症改善慢性脑灌注不足的认知障碍。Animal Model:SD rats, FeCl3-induced arterial thrombosis model
Dosage:0.1, 1, or 10 mg/kg
Administration:Intraperitoneal injection, 30 min before 35% FeCl3 treatment
Result:Significantly improved blood flow by inhibiting occlusion and thrombus formation. Prevented collagen fiber damage in injured vessels and inhibited the expression of the platelet activation-related proteins P-selectin and E-selectin. Significantly reduced the increased inflammatory signal of nuclear factor (NF)-κB, toll-like receptor 4 (TLR4), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 in blood vessels.
Animal Model:Male Wistar rats, Chronic cerebral hypoperfusion (CCH) model
Dosage:20, 40, or 80 mg/kg
Administration:Oral, once a day for 42 days
Result:Significantly improved cognitive impairment. Inhibited cholinergic system dysfunction, attenuated choline acetyltransferase-positive cholinergic neuron loss. Inhibited myelin basic protein degradation and increased the hippocampal expression of synaptic markers and cognition-related proteins. Reduced neuroinflammation, inhibited gliosis, and attenuated the activation of P2X7 receptor, TLR4/MyD88, NLRP3, and NF-κB.
Animal Model:SD rats
Dosage:2 or 10 mg/kg
Administration:IV or PO (Pharmacokinetic Analysis)
Result:Plasma pharmacokinetic parameters of Mumefural in SD ratsT1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-t (ng?h/mL) F (%)
IV (2 mg/kg)0.14±0.050.08±01894.54±580.66564.73±178.35-
PO (2 mg/kg)0.69±0.690.31±0.131731.61±290.641043.28±202.3736.95±7.17
AUC(0–t): area under the curve from the time of dosing to infinity; Cmax: maximum concentration; F: bioavailability; T1/2: terminal half-life; Tmax: time of the maximum concentration; SD: standard deviation; F was calculated using the following formula
Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. Mumefural inhibits platelet aggregation. Mumefural shows anti-thrombotic effects and ameliorates cognitive impairment.
体内研究：
Mumefural (0.1-10 mg/kg; i.p.; once) 在大鼠中显示抗血栓作用。Mumefural (20-80 mg/kg; oral; daily for 42 days) 通过调节中隔海马胆碱能系统和神经炎症改善慢性脑灌注不足的认知障碍。Animal Model:SD rats, FeCl3-induced arterial thrombosis model
Dosage:0.1, 1, or 10 mg/kg
Administration:Intraperitoneal injection, 30 min before 35% FeCl3 treatment
Result:Significantly improved blood flow by inhibiting occlusion and thrombus formation. Prevented collagen fiber damage in injured vessels and inhibited the expression of the platelet activation-related proteins P-selectin and E-selectin. Significantly reduced the increased inflammatory signal of nuclear factor (NF)-κB, toll-like receptor 4 (TLR4), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 in blood vessels.
Animal Model:Male Wistar rats, Chronic cerebral hypoperfusion (CCH) model
Dosage:20, 40, or 80 mg/kg
Administration:Oral, once a day for 42 days
Result:Significantly improved cognitive impairment. Inhibited cholinergic system dysfunction, attenuated choline acetyltransferase-positive cholinergic neuron loss. Inhibited myelin basic protein degradation and increased the hippocampal expression of synaptic markers and cognition-related proteins. Reduced neuroinflammation, inhibited gliosis, and attenuated the activation of P2X7 receptor, TLR4/MyD88, NLRP3, and NF-κB.
Animal Model:SD rats
Dosage:2 or 10 mg/kg
Administration:IV or PO (Pharmacokinetic Analysis)
Result:Plasma pharmacokinetic parameters of Mumefural in SD ratsT1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-t (ng?h/mL) F (%)
IV (2 mg/kg)0.14±0.050.08±01894.54±580.66564.73±178.35-
PO (2 mg/kg)0.69±0.690.31±0.131731.61±290.641043.28±202.3736.95±7.17
AUC(0–t): area under the curve from the time of dosing to infinity; Cmax: maximum concentration; F: bioavailability; T1/2: terminal half-life; Tmax: time of the maximum concentration; SD: standard deviation; F was calculated using the following formula
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