产品
编 号：F750058
分子式：C45H51N5O7
分子量：773.92
分子式：C45H51N5O7
分子量：773.92
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CAS No: 2227443-66-3
产品详情
生物活性：
NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC50s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia.
体内研究：
NaPi2b-IN-3 (1 mg/kg for IV and 10mg/kg for PO; single dosage) exhibits good activity and moderate hydrophobicity, and systemically exposes to some extent.Pharmacokinetic Parameters of NaPi2b-IN-3 in male Sprague-Dawley rats.IV (1 mg/kg) PO (10 mg/kg)
AUC0-t (h·ng/mL)834 ± 3531090 ± 430
Cmax (ng/mL)568 ± 261
F (%)13.1
Animal Model:Sprague-Dawley rats
Dosage:1 and 10 mg/kg
Administration:IV and PO; single dosage
Result:Exhibited good activity and moderate hydrophobicity and systemically exposed to some extent.
NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC50s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia.
体内研究：
NaPi2b-IN-3 (1 mg/kg for IV and 10mg/kg for PO; single dosage) exhibits good activity and moderate hydrophobicity, and systemically exposes to some extent.Pharmacokinetic Parameters of NaPi2b-IN-3 in male Sprague-Dawley rats.IV (1 mg/kg) PO (10 mg/kg)
AUC0-t (h·ng/mL)834 ± 3531090 ± 430
Cmax (ng/mL)568 ± 261
F (%)13.1
Animal Model:Sprague-Dawley rats
Dosage:1 and 10 mg/kg
Administration:IV and PO; single dosage
Result:Exhibited good activity and moderate hydrophobicity and systemically exposed to some extent.
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