产品
编 号：F749997
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规格
价格
是否有货
1mg
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询价
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CAS No: 2227102-46-5
产品详情
生物活性：
Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity.
体外研究：
Patritumab deruxtecan 对表达 HER3 突变的乳腺癌细胞表现出活性，无论HER2是否过表达。Patritumab deruxtecan (0-100 nM) 以浓度依赖性方式结合所有 HER3 突变体和 HER3WT MDA-MB-231 细胞的表面，但不结合 HER3EV 细胞.
Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity.
体外研究：
Patritumab deruxtecan 对表达 HER3 突变的乳腺癌细胞表现出活性，无论HER2是否过表达。Patritumab deruxtecan (0-100 nM) 以浓度依赖性方式结合所有 HER3 突变体和 HER3WT MDA-MB-231 细胞的表面，但不结合 HER3EV 细胞.
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