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编 号:F749945
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CAS No: 2225850-33-7
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生物活性:
Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor.
体内研究:
Zelminemab(10 mg/kg;i.v.;一次)降低 TCC 中的伤害性神经元活动。Animal Model:Sprague-Dawley rats, electricalstimulation was performed on the intact dura mater abovethe middle meningeal artery.
Dosage:10 mg/kg
Administration:i.v.; once
Result:Induced an inhibition of stimulus-evoked nociceptive activity in the trigeminocervical com-plex (TCC).