产品
编 号：F749919
分子式：C13H10F3N3O5
分子量：345.23
分子式：C13H10F3N3O5
分子量：345.23
产品类型
规格
价格
是否有货
结构图
CAS No: 2222660-40-2
产品详情
生物活性：
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.
体内研究：
DNDI-8219 (50 or 100 mg/kg; PO; once daily for five days) completely cures chronic infection, as well as markedly reduces?parasite burdens?in mice.Animal Model:Female BALB/c mice (infected with T.?cruzi; n=5)
Dosage:50 or 100 mg/kg
Administration:PO; once daily for five days
Result:Completely cured one of five mice in a chronic infection mouse model, as well as markedly reduced?parasite burdens?in two other mice.
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.
体内研究：
DNDI-8219 (50 or 100 mg/kg; PO; once daily for five days) completely cures chronic infection, as well as markedly reduces?parasite burdens?in mice.Animal Model:Female BALB/c mice (infected with T.?cruzi; n=5)
Dosage:50 or 100 mg/kg
Administration:PO; once daily for five days
Result:Completely cured one of five mice in a chronic infection mouse model, as well as markedly reduced?parasite burdens?in two other mice.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备