产品
编 号：F749805
分子式：C16H13F6NS2
分子量：397.4
分子式：C16H13F6NS2
分子量：397.4
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2204280-41-9
产品详情
生物活性：
MY33-3 is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction.
体内研究：
MY33-3 (60 mg/kg; p.o. on days 3 and 4) reduces ethanol consumption when comparing day 2 with day 3. MY33-3 reduces preference for the ethanol solution on day 3.MY33-3 (i.p.) reverses the Sevoflurane-induced decrease in the discrimination index and impaired motor learning ability.Animal Model:Male C57BL/6J mice (8-10 weeks of age) are received two-bottle drinking in the dark (DID) procedure using 20% ethanol
Dosage:60 mg/kg
Administration:P.o. 1 hour before the drinking session in the DID test on days 3 and 4
Result:Reduced ethanol consumption when comparing day 2 with day 3.Showed a reduced preference for the ethanol solution.Not affected total fluid consumption.
体外研究：
MY33-3 (1 μM; pretreated for 5 min) blocks Ethanol-induced activation of TrkA and ALK in SH-SY5Y cells.MY33-3 (0.1-10 μM; 24 h) limits LPS-induced nitrites production and iNos increases in BV2 microglial cells.
MY33-3 is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction.
体内研究：
MY33-3 (60 mg/kg; p.o. on days 3 and 4) reduces ethanol consumption when comparing day 2 with day 3. MY33-3 reduces preference for the ethanol solution on day 3.MY33-3 (i.p.) reverses the Sevoflurane-induced decrease in the discrimination index and impaired motor learning ability.Animal Model:Male C57BL/6J mice (8-10 weeks of age) are received two-bottle drinking in the dark (DID) procedure using 20% ethanol
Dosage:60 mg/kg
Administration:P.o. 1 hour before the drinking session in the DID test on days 3 and 4
Result:Reduced ethanol consumption when comparing day 2 with day 3.Showed a reduced preference for the ethanol solution.Not affected total fluid consumption.
体外研究：
MY33-3 (1 μM; pretreated for 5 min) blocks Ethanol-induced activation of TrkA and ALK in SH-SY5Y cells.MY33-3 (0.1-10 μM; 24 h) limits LPS-induced nitrites production and iNos increases in BV2 microglial cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备