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编 号：F749795
分子式：C30H35FN8O
分子量：542.65
分子式：C30H35FN8O
分子量：542.65
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CAS No: 2202767-78-8
产品详情
生物活性：
Cimpuciclib is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity.
体内研究：
Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) inhibits tumor growth in colo205 tumor-bearing mice.Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) shows slow metabolic rate and maintains high concentration in the plasma.Animal Model:Colo205 tumor-bearing mice
Dosage:50 mg/kg, twice a week
Administration:Oral gavage
Result:Inhibited tumor growth by 93.63%.
Animal Model:Rats, colo205 tumor-bearing mice
Dosage:5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
Administration:Oral administration
Result:Pharmacokinetic profile of Cimpuciclib (example 63). dose (mg/kg) Cmax (ng/mL)Tmax (h) AUC0-24 (ng/mL?h) t1/2 (h)
5 mg/kg (rats)559.7654142.4
50 mg/kg (mice)7960113678214.8
体外研究：
Cimpuciclib (example 63, 141.2 nM, 6 days) inhibits proliferation in colo205 cells.
Cimpuciclib is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity.
体内研究：
Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) inhibits tumor growth in colo205 tumor-bearing mice.Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) shows slow metabolic rate and maintains high concentration in the plasma.Animal Model:Colo205 tumor-bearing mice
Dosage:50 mg/kg, twice a week
Administration:Oral gavage
Result:Inhibited tumor growth by 93.63%.
Animal Model:Rats, colo205 tumor-bearing mice
Dosage:5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
Administration:Oral administration
Result:Pharmacokinetic profile of Cimpuciclib (example 63). dose (mg/kg) Cmax (ng/mL)Tmax (h) AUC0-24 (ng/mL?h) t1/2 (h)
5 mg/kg (rats)559.7654142.4
50 mg/kg (mice)7960113678214.8
体外研究：
Cimpuciclib (example 63, 141.2 nM, 6 days) inhibits proliferation in colo205 cells.
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