产品
编 号：F749755
分子式：C48H44Cl5MnN8
分子量：965.12
分子式：C48H44Cl5MnN8
分子量：965.12
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 219818-60-7
产品详情
生物活性：
MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porphyrin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer.
体内研究：
MnTE2-PyP decreases tumor volume and increases survival in vivo mouse model of prostate cancer. MnTE-2-PyP reduces blood glucose and inhibits pro-fibrotic signaling in a diabetic model.
体外研究：
MnTE-2-PyP (30 μM) protects against hyperglycemiainduced cell death after radiation. MnTE-2-PyP (30 μM) decreases expression of NOX4 and a-SMA, one of the major oxidative enzymes and pro-fibrotic molecules respectively. MnTE-2-PyP (30 μM, 5 days) obstructs NF-kB activity by decreasing DNA binding of the p50-p50 homodimer in the irradiated hyperglycemic environment. MnTE-2-PyP (30 μM) increases NRF2 mediated cytoprotection by increasing NRF2 protein expression and DNA binding.
MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porphyrin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer.
体内研究：
MnTE2-PyP decreases tumor volume and increases survival in vivo mouse model of prostate cancer. MnTE-2-PyP reduces blood glucose and inhibits pro-fibrotic signaling in a diabetic model.
体外研究：
MnTE-2-PyP (30 μM) protects against hyperglycemiainduced cell death after radiation. MnTE-2-PyP (30 μM) decreases expression of NOX4 and a-SMA, one of the major oxidative enzymes and pro-fibrotic molecules respectively. MnTE-2-PyP (30 μM, 5 days) obstructs NF-kB activity by decreasing DNA binding of the p50-p50 homodimer in the irradiated hyperglycemic environment. MnTE-2-PyP (30 μM) increases NRF2 mediated cytoprotection by increasing NRF2 protein expression and DNA binding.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备