产品
编 号:F749589
分子式:C20H21N3O5S
分子量:415.46
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1mg
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5mg
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10mg
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25mg
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生物活性:
Cjoc42 is a compound capable of binding to gankyrin. Cjoc42 inhibits gankyrin activity in a dose-dependent manner. Cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin. Cjoc42 restores p53-dependent transcription and sensitivity to DNA damage.

体外研究:
cjoc42 (0.5, 1, and 5 μM; 48 hours) dose-dependently restores p53 levels (comparable to mock transfected cells) and inhibits gankyrin-induced lowering of p53 levels in cells.cjoc42 (0.1, 1, and 10 μM; 24 hours) alone shows no dose-dependent change in cell viability.
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