产品
编 号：F749545
分子式：C18H23NO4
分子量：317.38
分子式：C18H23NO4
分子量：317.38
产品类型
规格
价格
是否有货
结构图
CAS No: 2170274-53-8
产品详情
生物活性：
SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway.
体内研究：
SPC-180002（1-5mg/kg，每周两次，腹腔注射）可抑制多种癌细胞的生长，并阻碍 MCF7 肿瘤异种移植小鼠中的肿瘤生长。Animal Model:Five weeks female athymic nude mice (BALB/c)
Dosage:1 mg/kg or 5 mg/kg
Administration:i.p., twice a week
Result:Significantly impeded tumor progression. The gain of tumor volume in SPC-180002-treated mice was significantly reduced by 48% at the low dose (1 mg/kg) and by 52% at the high dose (5 mg/kg), compared to vehicle-treated mice.
体外研究：
SPC-180002（0-5 μM，24 小时）通过 p21 积累抑制细胞周期进程，从而导致随后的细胞衰老。SPC-180002 不会诱导细胞凋亡和自噬。
SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway.
体内研究：
SPC-180002（1-5mg/kg，每周两次，腹腔注射）可抑制多种癌细胞的生长，并阻碍 MCF7 肿瘤异种移植小鼠中的肿瘤生长。Animal Model:Five weeks female athymic nude mice (BALB/c)
Dosage:1 mg/kg or 5 mg/kg
Administration:i.p., twice a week
Result:Significantly impeded tumor progression. The gain of tumor volume in SPC-180002-treated mice was significantly reduced by 48% at the low dose (1 mg/kg) and by 52% at the high dose (5 mg/kg), compared to vehicle-treated mice.
体外研究：
SPC-180002（0-5 μM，24 小时）通过 p21 积累抑制细胞周期进程，从而导致随后的细胞衰老。SPC-180002 不会诱导细胞凋亡和自噬。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备