产品
编 号：F749428
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规格
价格
是否有货
1mg
询价
询价
5mg
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询价
结构图
CAS No: 2159141-27-0
产品详情
生物活性：
Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease.
体内研究：
Semorinemab (3，10 和 30 mg/kg；腹腔注射，每周一次，持续 13 周) 减少 Tau 病状的转基因 (Tg) 小鼠模型中 Tau 的积累。Animal Model:Tg mouse with the expression of human disease-causing tau mutant (TauP301L-Tg)
Dosage:3, 10 and 30 mg/kg
Administration:Intraperitoneal injection; 3, 10 and 30 mg/kg, once weekly for 13 weeks
Result:Reduced the accumulation of pathological tau, and dose-dependently decreased pTau212/214 and pTau202/205.
体外研究：
Semorinemab 与人 Tau 蛋白和重组食蟹猴 Tau 蛋白结合的 Kd 值分别为 3.8 和 11.2 nM。Semorinemab 阻止神经元摄取低聚 Tau。
Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease.
体内研究：
Semorinemab (3，10 和 30 mg/kg；腹腔注射，每周一次，持续 13 周) 减少 Tau 病状的转基因 (Tg) 小鼠模型中 Tau 的积累。Animal Model:Tg mouse with the expression of human disease-causing tau mutant (TauP301L-Tg)
Dosage:3, 10 and 30 mg/kg
Administration:Intraperitoneal injection; 3, 10 and 30 mg/kg, once weekly for 13 weeks
Result:Reduced the accumulation of pathological tau, and dose-dependently decreased pTau212/214 and pTau202/205.
体外研究：
Semorinemab 与人 Tau 蛋白和重组食蟹猴 Tau 蛋白结合的 Kd 值分别为 3.8 和 11.2 nM。Semorinemab 阻止神经元摄取低聚 Tau。
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