产品
编 号：F077012
分子式：C18H31ClN2O2S
分子量：374.97
分子式：C18H31ClN2O2S
分子量：374.97
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CAS No: 1217674-10-6
产品详情
生物活性：
SB 258719 hydrochloride is a selective 5-HT7 receptor antagonist displayed high affnity (pKi=7.5) for the receptor. SB-258719 hydrochloride can be used for the research of cancer and neurological diseases.
体内研究：
SB-258719 (5~20 mg/kg; i.p.) hydrochloride significantly attenuates the 5-CT-induced hypothermia.Animal Model:Male Swiss Webster mice (20~25 g).
Dosage:5~20 mg/kg
Administration:I.p.
Result:Significantly attenuated the 5-CT-induced hypothermia.
体外研究：
SB-258719 (1, 3 and 10 μM; HEK 293 cells) hydrochloride produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT.
SB 258719 hydrochloride is a selective 5-HT7 receptor antagonist displayed high affnity (pKi=7.5) for the receptor. SB-258719 hydrochloride can be used for the research of cancer and neurological diseases.
体内研究：
SB-258719 (5~20 mg/kg; i.p.) hydrochloride significantly attenuates the 5-CT-induced hypothermia.Animal Model:Male Swiss Webster mice (20~25 g).
Dosage:5~20 mg/kg
Administration:I.p.
Result:Significantly attenuated the 5-CT-induced hypothermia.
体外研究：
SB-258719 (1, 3 and 10 μM; HEK 293 cells) hydrochloride produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT.
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