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编 号：F749207
分子式：C27H44O3
分子量：416.64
分子式：C27H44O3
分子量：416.64
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CAS No: 213250-70-5
产品详情
生物活性：
2MD is an orally active vitamin D analog. 2MD stimulates periosteal bone formation and decreases trabecular bone resorption. Thus 2MD restores trabecular and cortical bone mass and strength. 2MD also regulates intraocular pressure (IOP)-relative genes and reduces IOP in non-human primates.
体内研究：
2MD (5 μg/eye; 滴注; 单次剂量) 处理 7-8 小时后，可使食蟹猴同侧眼眼压逐渐降低 20%，对侧眼眼压逐渐降低至 15% 或更低。2MD (0.5-10 ng/kg, 0,1 mL/day; 口服给药; 每天 1 次, 共 16 周) 不仅可以恢复骨小梁和皮质骨质量，还可以通过刺激骨膜表面骨形成和减少骨小梁表面骨吸收，增加大鼠的骨质量和强度。Animal Model:Ovariectomized (OVX) rats model (Sprague-Dawley female rats; 4-month-old)
Dosage:0.5, 1, 2.5, 5, and 10 ng/kg, 0,1 mL/day
Administration:Oral gavage; once daily for 16 weeks
Result:Significantly increased serum calcium at 2.5, 5, or 10 ng/kg/day.Dose-dependent reduction in osteoclast number and trabecular osteoclast surface, and dose-dependent increased in periosteal bone formation.
2MD is an orally active vitamin D analog. 2MD stimulates periosteal bone formation and decreases trabecular bone resorption. Thus 2MD restores trabecular and cortical bone mass and strength. 2MD also regulates intraocular pressure (IOP)-relative genes and reduces IOP in non-human primates.
体内研究：
2MD (5 μg/eye; 滴注; 单次剂量) 处理 7-8 小时后，可使食蟹猴同侧眼眼压逐渐降低 20%，对侧眼眼压逐渐降低至 15% 或更低。2MD (0.5-10 ng/kg, 0,1 mL/day; 口服给药; 每天 1 次, 共 16 周) 不仅可以恢复骨小梁和皮质骨质量，还可以通过刺激骨膜表面骨形成和减少骨小梁表面骨吸收，增加大鼠的骨质量和强度。Animal Model:Ovariectomized (OVX) rats model (Sprague-Dawley female rats; 4-month-old)
Dosage:0.5, 1, 2.5, 5, and 10 ng/kg, 0,1 mL/day
Administration:Oral gavage; once daily for 16 weeks
Result:Significantly increased serum calcium at 2.5, 5, or 10 ng/kg/day.Dose-dependent reduction in osteoclast number and trabecular osteoclast surface, and dose-dependent increased in periosteal bone formation.
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